HS research update (2026-09-15): What's new on PubMed?

Publication overview

This update includes 24 PubMed publications with abstracts from the monitoring window 2026-09-01 to 2026-09-15. The most common themes are comorbiditiesComorbidity: An additional condition existing alongside the primary disease. Acne Inversa is frequently associated with comorbidities including metabolic syndrome, inflammatory bowel disease, spondyloarthritis, and depression.ComorbidityAn additional condition existing alongside the primary disease. Acne Inversa is frequently associated with comorbidities including metabolic syndrome, inflammatory bowel disease, spondyloarthritis, and depression.Read more in the glossary, biologicsBiologic: A class of medications derived from living cells that target specific components of the inflammatory process. For Acne Inversa, biologics such as adalimumab and secukinumab are used when other treatments are insufficient.BiologicA class of medications derived from living cells that target specific components of the inflammatory process. For Acne Inversa, biologics such as adalimumab and secukinumab are used when other treatments are insufficient.Read more in the glossary, wound care, pain, jak inhibitor.

• Compared with the previous update: not automatically assessed.
• No guideline/NEJM/Lancet-style high-impact matches with abstracts in this window.
• This is a research overview, not a guideline update or medical recommendation.

Top highlights

The most useful signal this round is not a single treatment instruction. It is what researchers are looking at more closely: wound healing after procedures, possible new anti-inflammatory approaches, care quality, and comorbidities.

• Case report of three cases and literature review: is follicular occlusionFollicular Occlusion: The blockage of hair follicles is considered a key starting point in the development of Acne Inversa. When a follicle becomes obstructed, inflammation can spread deep into tissue, leading to nodules, abscesses, and sinus tracts.Follicular OcclusionThe blockage of hair follicles is considered a key starting point in the development of Acne Inversa. When a follicle becomes obstructed, inflammation can spread deep into tissue, leading to nodules, abscesses, and sinus tracts.Read more in the glossary triad with peripheral/axial spondyloarthritisSpondyloarthritis: A family of inflammatory joint and spine conditions (including ankylosing spondylitis, psoriatic arthritis) that overlap with Acne Inversa. If you have HS and unexplained inflammatory back pain (morning stiffness lasting more than 30 minutes, better with movement), an assessment is worthwhile.SpondyloarthritisA family of inflammatory joint and spine conditions (including ankylosing spondylitis, psoriatic arthritis) that overlap with Acne Inversa. If you have HS and unexplained inflammatory back pain (morning stiffness lasting more than 30 minutes, better with movement), an assessment is worthwhile.Read more in the glossary involvement an analog of SAPHO syndrome?: The abstract describes a new publication. In practical terms, it focuses on this question or finding: SAPHO syndrome is a rare chronic rheumatic disease characterized by five typical manifestations: synovitis, acne, pustulosis, hyperostosis, and osteitis. The follicular occlusion triad (FOT) comprises hidradenitis sup… What makes it notable here is that it approaches HS through pain, comorbidities, biologics. The main limitation to keep in mind is: From the abstract alone, it is hard to judge the study design, patient selection, and follow-up in full. (PMID 42707673)
• Case Report: Achilles enthesitis as the presenting clue to occult sacroiliitis in hidradenitis suppurativa.: The abstract describes a new publication. In practical terms, it focuses on this question or finding: Hidradenitis suppurativa is increasingly recognized as a systemic inflammatory disease with an established overlap with spondyloarthritis. Axial spondyloarthritis is usually suspected when patients report inflammatory… What makes it notable here is that it approaches HS through pain, comorbidities, biologics. The main limitation to keep in mind is: From the abstract alone, it is hard to judge the study design, patient selection, and follow-up in full. (PMID 42688744)
• Psoriasiform Dermatitis Following JAK Inhibitor Therapy for Hidradenitis Suppurativa and Crohn’s Disease.: The abstract describes a new publication. In practical terms, it focuses on this question or finding: UpadacitinibUpadacitinib: An oral JAK1 inhibitor already approved for rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis, and Crohn's disease. Studied off-label and in trials for Acne Inversa. Brand name: Rinvoq®.UpadacitinibAn oral JAK1 inhibitor already approved for rheumatoid arthritis, psoriatic arthritis, atopic dermatitis, ulcerative colitis, and Crohn's disease. Studied off-label and in trials for Acne Inversa. Brand name: Rinvoq®.Read more in the glossary, a selective JAK1 inhibitor approved for hidradenitis suppurativa (HS) and Crohn’s disease (CD), has been implicated in paradoxical inflammatory reactions; however, upadacitinib-induced psoriasiform derma… What makes it notable here is that it approaches HS through jak inhibitor, comorbidities, biologics. The main limitation to keep in mind is: From the abstract alone, it is hard to judge the study design, patient selection, and follow-up in full. (PMID 42699819)
• Recent advances in hidradenitis suppurativa therapeutics: a focus on existing and future medical therapeutics.: The abstract describes a new publication. In practical terms, it focuses on this question or finding: HS is an inflammatory skin condition that causes abscessesAbscess: An inflamed cavity or swelling containing pus or fluid. In hidradenitis suppurativa, abscesses can form as part of the inflammatory disease process and do not automatically mean that a bacterial infection is present. Secondary bacterial infection can occur and may require separate medical assessment. In Acne Inversa, abscesses occur mainly in the armpits, groin, and other skin folds.AbscessAn inflamed cavity or swelling containing pus or fluid. In hidradenitis suppurativa, abscesses can form as part of the inflammatory disease process and do not automatically mean that a bacterial infection is present. Secondary bacterial infection can occur and may require separate medical assessment. In Acne Inversa, abscesses occur mainly in the armpits, groin, and other skin folds.Read more in the glossary, nodulesNodule: A firm, palpable lump deep in tissue. Nodules can be painful and may progress to abscesses. They are among the typical early signs of Acne Inversa.NoduleA firm, palpable lump deep in tissue. Nodules can be painful and may progress to abscesses. They are among the typical early signs of Acne Inversa.Read more in the glossary, and tunnelsSinus Tract: A tunnel-like channel under the skin that forms between abscesses or nodules. Sinus tracts indicate more advanced disease and can chronically drain fluid. They are associated with Hurley Stages II and III.Sinus TractA tunnel-like channel under the skin that forms between abscesses or nodules. Sinus tracts indicate more advanced disease and can chronically drain fluid. They are associated with Hurley Stages II and III.Read more in the glossary in intertriginous areas. Treatment consists of multimodal therapy such as topical and systemic antibiotics, washes and ointments, hormon… What makes it notable here is that it approaches HS through surgery, jak inhibitor, biologics. The main limitation to keep in mind is: From the abstract alone, it is hard to judge the study design, patient selection, and follow-up in full. (PMID 42700395)
• Surgical Management of Hidradenitis Suppurativa Using Staged Carbon Dioxide Laser Marsupialization.: The abstract describes a new publication. In practical terms, it focuses on this question or finding: Hidradenitis suppurativa (HS) is a chronic disease marked by symptoms of pain, drainage, and odor. Persistent abscesses, nodules, and scarred tunnels can be resistant to pharmacologic management, with chronic lesions… What makes it notable here is that it approaches HS through wound care, surgery, pain. The main limitation to keep in mind is: From the abstract alone, it is hard to judge the study design, patient selection, and follow-up in full. (PMID 42739657)

Featured publication

The featured paper is Case report of three cases and literature review: is follicular occlusion triad with peripheral/axial spondyloarthritis involvement an analog of SAPHO syndrome? in Frontiers in medicine (PMID 42707673). The abstract mainly says this: SAPHO syndrome is a rare chronic rheumatic disease characterized by five typical manifestations: synovitis, acne, pustulosis, hyperostosis, and osteitis. The follicular occlusion triad (FOT) comprises hidradenitis sup…

Why it stands out: it connects to the priority themes pain, comorbidities, biologics and shows what HS researchers are trying to clarify right now. For readers, it matters because it gives one concrete example of how the field is framing a practical question or possible mechanism. The main limitation is that From the abstract alone, it is hard to judge the study design, patient selection, and follow-up in full.

What this may mean for patients (carefully, no advice)

If you live with HS, research updates can help you make sense of what’s being studied — for example which outcomes (pain, quality of life) researchers measure, or which comorbidities are increasingly part of the conversation.

But even when a study sounds promising, it usually does not tell you what is right for you personally. Consider using new findings as questions for your next appointment (e.g., “What are realistic goals for me?” or “Which related conditions should we keep an eye on?”), not as instructions.

What we don’t know / limitations

• This update includes only PubMed items with an abstract (without an abstract, safe summarization is limited).
• Studies vary widely (design, populations, outcome measures).
• This update provides no treatment advice and cannot assess individual risk.

Important: decisions belong in clinician conversations

This article is an editorial overview and is not medically reviewed. If something here worries or interests you, use it as a conversation starter for your next appointment. Decisions should always be made with qualified healthcare professionals.

FAQ

Why are there only a few new publications here?

This format is deliberately strict: it includes only new PubMed items from the monitoring window that have an abstract and were not already covered in earlier posts.

Does a new paper mean my treatment should change?

No. A single publication can be useful to know about, but it is usually not enough to guide decisions for one specific person.

Why emphasize limitations so much?

Because abstracts show only part of the picture. Study design, patient population, endpoints, and follow-up all matter before results can be interpreted responsibly.

Sources & original papers

Each point below maps to an original source (PubMed link, plus DOI/PMCID when available).