HS Research Update (May 20, 2026): What's New on PubMed? Canonical URL: https://www.acneinversa.life/en/blog/hs-research-update-2026-05-20/ Markdown URL: https://www.acneinversa.life/en/blog/hs-research-update-2026-05-20.md Plain text URL: https://www.acneinversa.life/en/blog/hs-research-update-2026-05-20.txt Language: en Category: Research Published: 2026-05-20 Last updated: 2026-05-20 Last editorially reviewed: 2026-05-20 Next scheduled review: 2027-05-20 Author: Dr. rer. nat. Dennis Alexander Kwiatkowski (Biochemist, Scientific Writer and Pharma Expert) Scientific editor: Dr. rer. nat. Dennis Alexander Kwiatkowski Reviewer qualifications: Biochemist, Scientific Writer and Pharma Expert Review scope: Scientific literature, clinical guidelines, sources, and editorial clarity Clinical reviewer: No independent clinical review Tags: Acne Inversa, Hidradenitis Suppurativa, HS, Research, hidradenitis suppurativa, acne inversa, research update, biologics, comorbidities, diagnostic delay, pain, quality of life, surgery A patient-friendly overview of new PubMed publications on Hidradenitis suppurativa (Acne inversa) – with sources, clear limitations, and no medical advice. Medical disclaimer: This website is for general educational information only and does not replace medical advice, diagnosis, or treatment. Please speak with qualified medical professionals about symptoms or treatment decisions. Article Note: This article is an editorial overview and has not been medically reviewed. It does not replace medical advice, diagnosis, or treatment. What this update covers - Search query: ("hidradenitis suppurativa" OR "acne inversa") - Entrez date field: edat - Time period: May 12, 2026 to May 20, 2026 - Newly added PubMed entries: 15 Key findings In short: this week's abstracts focus on patient-relevant outcomes (pain/quality of life), practical care questions, and signals related to comorbidities. - Comorbidities and systemic aspects (e.g., metabolic, musculoskeletal, IBD) come up repeatedly. (PMIDs 42147604, 42117990, 42153035, 42156635) - Some abstracts address surgical/structural issues (e.g., fistulas/complications) related to HS care. (PMIDs 42131295, 42137224, 42117990) - Pain and disease control are increasingly being treated as explicit study endpoints and goals. (PMIDs 42131295, 42137224) - Several abstracts focus on quality of life, stigma, and patient-relevant outcome measures (e.g., DLQI/HiSQOL). (PMIDs 42131295, 42137224) What this could mean for patients (cautiously, not advice) If you live with HS, research updates can help you understand what is currently being studied – for example, which endpoints (pain, quality of life) researchers measure or which comorbidities are increasingly part of the discussion. If the condition is new to you, our overview of what Acne inversa is (/en/blog/what-is-acne-inversa/) may provide helpful context for these terms. But even when a study sounds promising, it usually doesn't tell you what's right for you personally. Consider using new findings as questions for your next doctor's appointment (/en/blog/15-questions-to-ask-your-dermatologist/) (e.g., "What goals are realistic for me?" or "Which related conditions should we watch for?"), not as instructions. What we don't know / Limitations - This update includes only PubMed entries with an abstract (without an abstract, a reliable summary is only possible to a limited extent). - The studies vary widely (design, populations, outcome measures). - This update does not provide treatment recommendations and cannot assess individual risk. Overview of publications - Publications (with abstracts) in this period: 15 - Common themes: comorbidities, quality of life, biologics, surgery, pain - Comparison with the previous week: not yet available (this is the first update in this series). - No guideline-/NEJM-/Lancet-type high-impact hits with abstracts in this period. - Featured publication: Clinical, Cosmetic and Investigational Dermatology – focus on quality of life/disease burden and how studies measure it. (PMID 42131295) Important: Decisions belong in conversation with medical professionals If anything here concerns or interests you, use it as a conversation starter for your next appointment. Recognizing patterns early can also be important – see our guide on recognizing Hidradenitis suppurativa before it progresses (/en/blog/recognizing-hidradenitis-suppurativa-early/). Decisions should always be made together with qualified medical professionals. Sources & original publications Each point below refers to an original source (PubMed link as well as DOI/PMCID, where available). FAQ What does this HS research update cover? It summarizes 15 PubMed publications on Hidradenitis suppurativa (Acne inversa) indexed between May 12 and May 20, 2026, with a focus on quality of life, comorbidities, surgery, and pain. Is this medical advice? No. This is an editorial overview for patient education. It has not been medically reviewed and does not replace advice, diagnosis, or treatment by qualified medical professionals. How should I use this update? Use it as a conversation starter for your next dermatology appointment – for example, to ask about realistic treatment goals or which comorbidities should be monitored. Why are quality-of-life measures important in HS research? Because HS affects pain, mental health, and everyday functioning, researchers increasingly use patient-reported outcome measures (e.g., DLQI or HiSQOL) to capture the true burden beyond visible skin changes. References 1. The Role of Inflammatory Biomarkers in Disease Severity and Treatment Response across Psoriasis, Atopic Dermatitis, and Hidradenitis Suppurativa-A Narrative Review. - Dermatology and therapy, 2026 — PMID 42156635 · DOI 10.1007/s13555-026-01733-x - https://pubmed.ncbi.nlm.nih.gov/42156635/ 2. Global Healthcare Study on Psoriasis (GHSP): cohort profile and first findings. - BMJ open, 2026 — PMID 42156142 · DOI 10.1136/bmjopen-2025-112891 - https://pubmed.ncbi.nlm.nih.gov/42156142/ 3. Position Statement of the EADV Task Forces With External Experts on Quality of Life Measurement in Hidradenitis Suppurativa: An Update. - International journal of dermatology, 2026 — PMID 42144705 · DOI 10.1111/ijd.70443 - https://pubmed.ncbi.nlm.nih.gov/42144705/ 4. Patients' preference regarding patient reported outcome measures (PROMs) for hidradenitis suppurativa, a cross-sectional multi-center study. - Dermatology (Basel, Switzerland), 2026 — PMID 42139161 · DOI 10.1159/000552227 - https://pubmed.ncbi.nlm.nih.gov/42139161/ 5. New Hidradenitis Suppurativa in Children: Influence of Neighborhood Socioeconomic Status. - Pediatric dermatology, 2026 — PMID 42132305 · DOI 10.1111/pde.70265 - https://pubmed.ncbi.nlm.nih.gov/42132305/ 6. Laboratory Parameters Can Serve as Objective Auxiliary Tools for Assessing Disease Severity in Hidradenitis Suppurativa: A 5-Year Period Single-Center Retrospective Study. - Clinical, cosmetic and investigational dermatology, 2026 — PMID 42153035 · DOI 10.2147/CCID.S601760 · PMCID PMC13180368 - https://pubmed.ncbi.nlm.nih.gov/42153035/ 7. Spatially Profiling Trace Cytokine Signatures From Microscopically Derived Skin Samples to Probe Skin Disease Inflammation. - Small methods, 2026 — PMID 42124321 · DOI 10.1002/smtd.202501964 - https://pubmed.ncbi.nlm.nih.gov/42124321/ 8. High-Frequency Ultrasound in Hidradenitis Suppurativa: From Lesion Detection to Iconographic Lesion-Level Management. - American journal of clinical dermatology, 2026 — PMID 42118485 · DOI 10.1007/s40257-026-01040-3 - https://pubmed.ncbi.nlm.nih.gov/42118485/ 9. Defining Minimal Disease Activity in Hidradenitis Suppurativa: A New Clinical Target. - Journal of cutaneous medicine and surgery, 2026 — PMID 42117442 · DOI 10.1177/12034754261442925 - https://pubmed.ncbi.nlm.nih.gov/42117442/ 10. Impact of Bariatric Surgery on Quality of Life and Psychological Well-Being Among Patients with Hidradenitis Suppurativa: A Cross-Sectional Study. - Clinical, cosmetic and investigational dermatology, 2026 — PMID 42131295 · DOI 10.2147/CCID.S584656 · PMCID PMC13165486 - https://pubmed.ncbi.nlm.nih.gov/42131295/ 11. The Multifaceted Role of Keratinocytes in Hidradenitis Suppurativa Pathogenesis. - Experimental dermatology, 2026 — PMID 42124376 · DOI 10.1111/exd.70269 · PMCID PMC13168781 - https://pubmed.ncbi.nlm.nih.gov/42124376/ 12. How I Do It: MRI Approach to Perianal Fistulas. - Radiology, 2026 — PMID 42117990 · DOI 10.1148/radiol.251909 - https://pubmed.ncbi.nlm.nih.gov/42117990/ 13. Patterns of Musculoskeletal Involvement in Hidradenitis Suppurativa: A Pilot Study. - Cureus, 2026 — PMID 42147604 · DOI 10.7759/cureus.106996 · PMCID PMC13172419 - https://pubmed.ncbi.nlm.nih.gov/42147604/ 14. Severe Penoscrotal Lymphedema in Hidradenitis Suppurativa: A Case Series. - Skin appendage disorders, 2026 — PMID 42137224 · DOI 10.1159/000551470 · PMCID PMC13171140 - https://pubmed.ncbi.nlm.nih.gov/42137224/ 15. Viable vs. Nonviable Microbiota Evaluation of the Hair Follicle and Scalp Microbiome. - Methods in molecular biology (Clifton, N.J.), 2026 — PMID 42149452 · DOI 10.1007/978-1-0716-5253-4_18 - https://pubmed.ncbi.nlm.nih.gov/42149452/